FISH/CISH

In situ hybridisation (fluorescent for FISH and chromogenic for CISH) uses probes to analyse genetic changes (amplifications, deletions, translocations) in tumours. These probes are used to classify tumours (particularly in the case of lymphomas and soft tissue tumours) and identify prognostic factors or therapeutic targets for certain tumours (in the case of breast cancers or lung adenocarcinomas).